Сочетание Propionyl-L-Carnitine с Виагрой выявилось эффективней , чем одна виагра в лечении эректильной дисфункции . Это позволяет говорить о влиянии PLC на уровень оксида азота по аналогии с аргинином .
Propionyl-L-Carnitine
One study examined the use of two forms of carnitine, propionyl-L-carnitine and acetyl-L-carnitine in 96 men who with erectile dysfunction after prostate surgery. One group were given a placebo, another group took propionyl-L-carnitine (2 grams per day) plus acetyl-L-carnitine (2 grams per day) and sildenafil (Viagra) when needed, and the third group used Viagra alone.
Propionyl-L-carnitine and acetyl-L-carnitine were found to enhance the effectiveness of sildenafil, and result in improved erectile function, sexual intercourse satisfaction, orgasm, and general sexual well-being compared to Viagra alone.
Another study examined the effectiveness of propionyl-L-carnitine supplements plus sildenafil in men with erectile dysfunction and diabetes who were previously unresponsive to Viagra alone.
Participants in the study received either propionyl-L-carnitine (two grams per day) plus Viagra (50 milligrams twice a week) or Viagra alone. After 24 weeks, propionyl-L-carnitine plus Viagra was significantly more effective than Viagra alone.
Sources:
Cavallini G, Modenini F, Vitali G, Koverech A. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. Urology. 66.5 (2005): 1080-1085.
А также
Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men
Bloomer RJ, Smith WA, Fisher-Wellman KH.
Department of Health and Sport Sciences, University of Memphis, Memphis, TN, USA
уровень оксида азота в крови после 4.5 грамм GPLC
краткие характеристики исследования
ABSTRACT: : We have recently demonstrated that oral intake of glycine propionyl-L-carnitine (GPLC) increases plasma nitrate/nitrite (NOx), a surrogate measure of nitric oxide production. However, these findings were observed at rest, and in previously sedentary subjects. PURPOSE: In the present study, we sought to determine the impact of oral GPLC on plasma NOx at rest and in response to a period of reactive hyperemia in resistance trained men. METHODS: Using a double blind, crossover design, 15 healthy men (24 +/- 4 years) were assigned to GPLC (3 g/d PLC + 1044 mg glycine) and a placebo in random order, for a four-week period, with a two-week washout between condition assignment. Blood samples were taken from subjects at rest and at 0, 3, and 10 minutes following an ischemia-reperfusion protocol (six minutes of upper arm cuff occlusion at 200 mmHg followed by rapid reperfusion with cuff removal). Blood samples were taken from a forearm vein from the same arm used for the protocol and analyzed for total nitrate/nitrite. Data are presented as mean +/- SEM. RESULTS: A condition main effect (p = 0.0008) was noted for NOx, with higher values in subjects when using GPLC (45.6 +/- 2.8 mumol.L-1) compared to placebo (34.9 +/- 1.2 mumol.L-1). No time main effect was noted (p = 0.7099), although values increased approximately 12% from rest (37.7 +/- 2.7 mumol.L-1) to a peak at 10 minutes post protocol (42.3 +/- 3.3 mumol.L-1). The interaction effect was not significant (p = 0.8809), although paired time contrasts revealed higher values for GPLC compared to placebo at 3 (48.2 +/- 6.7 vs. 34.9 +/- 2.4 mumol.L-1; p = 0.033) and 10 (48.8 +/- 5.9 vs. 35.7 +/- 2.1 mumol.L-1; p = 0.036) minutes post protocol, with non-statistically significant differences noted at rest (41.8 +/- 4.5 vs. 33.6 +/- 2.5 mumol.L-1; p = 0.189) and at 0 minutes (43.6 +/- 5.1 vs. 35.4 +/- 2.7 mumol.L-1; p = 0.187) post protocol. An analysis by subject (collapsed across time) indicated that 11 of the 15 subjects experienced an increase in NOx with GPLC treatment. CONCLUSION: These findings indicate that short-term oral GPLC supplementation can increase NOx in resistance trained men. However, as with many dietary supplements, there exist both "responders" and "non-responders" to treatment. Future work may focus on the mechanisms for the discrepancy in response to GPLC supplementation for purposes of NOx elevation.
полный вариант статьи -
http://www.jissn.com/content/4/1/22
Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males.
Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ.
Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL 33314, USA. pjacobs4@fau.edu.
Abstract
GPLC доказал свою эффективность в анаэробной работе и может повысить результаты спортсменов .
краткая характеристика
ABSTRACT: BACKGROUND: Recent research has indicated that short term administration of glycine propionyl-L-carnitine (GPLC) significantly elevates levels of nitric oxide metabolites at rest and in response to reactive hyperaemia. However, no scientific evidence exists that suggests such supplementation enhances exercise performance in healthy, trained individuals. The purpose of this study was to examine the effects of GPLC on the performance of repeated high intensity stationary cycle sprints with limited recovery periods in resistance trained male subjects. METHODS: In a double-blind, placebo-controlled, cross-over design, twenty-four male resistance trained subjects (25.2 +/- 3.6 years) participated in two test sessions separated by one week. Testing was performed 90 minutes following oral ingestion of either 4.5 grams GPLC or 4.5 grams cellulose (PL), in randomized order. The exercise testing protocol consisted of five 10-second Wingate cycle sprints separated by 1-minute active recovery periods. Peak (PP) and mean values (MP) of sprint power output and percent decrement of power (DEC) were determined per bout and standardized relative to body masss. Heart rate (HR) and blood lactate (LAC) were measured prior to, during and following the five sprint bouts. RESULTS: Significant main effects (p < 0.001) were observed for sprint bout order in values of PP, MP, DEC, and HR. There were significant main effects detected for condition in PP and MP (p < 0.05), with values across the five sprint bouts 2.6 - 15% greater with GPLC. Significant statistical interactions were detected between bout order and condition for both PP and MP (p < 0.05). There was a significant main effect of condition for LAC, LAC values 15.7% lower 4 min post-exercise with GPLC (p = 0.09) and with GPLC resulting in 16.2% less LAC at 14 min post-exercise (p < 0.05). CONCLUSION: These findings indicate that short-term oral supplementation of GPLC can enhance peak power production in resistance trained males with significantly less LAC accumulation.
полный вариант -
http://www.jissn.com/content/6/1/9
А тут говорится о неэффективности аргинина даже в дозах 20+ грамм
Сообщение изменено: ^Infiniti^ (02 июня 2010 - 08:35)