>>Пишут, что заметное повышение уровня синтеза белка достигается через 3 недели
На какой странице это написано?
Muscle protein synthesis after mechanosensor signaling
We conclude that it is likely an increase in ribosome biogenesis (rather than the temporary increase in mRNA transcript number) that allows for this ‘‘time integration’’ of the signal. Its effect would be to suppress fluctuations in the concentration of TK conformations or signaling molecules, smoothly increasing the concentration of the structural muscle proteins over the time similar to the half-life of ribosomes. We suggest that this effect could help explain the delay of a few weeks between starting resistance exercise and the first detection of measurable muscle growth, as noted by trainers and rehabilitation specialists.
The constituent molecules of most signaling pathways have a short lifetime relative to that of the structural proteins. It is also well documented that a few bouts of exercise do not have a tangible effect on muscle volume and that muscle takes at least a few weeks to begin to show visible hypertrophic adaptations. The debate on whether true hypertrophy is soon detected or whether initial postexercise changes in muscle CSA are the signs of muscle microdamage is a rather fraught one (49–52).
Three weeks of resistance training appears to be a consensus time, after which true hypertrophy is actually detected. This means that there has to be a way of ‘‘integrating’’ the signal over such a long period of time, beyond the scope of the simple force integration supported by a metastable open state of TK. Here, we combine the above model of mechanosensitive signaling with a simple model of protein synthesis from a signaling molecule and propose a mechanism by which this integration may occur.
Я немного упростил, но смысл такой — нам пишут, что:
1) Однократной стимуляции как таковой - недостаточно; нужна серия последовательных стимуляций.
2) То есть на гипертрофию работает НЕ срочный сигналинг (во время тренировки, сразу после тренировки) - а длительный сигналинг во время восстановления, отдыха - через steady-state механосигналинг, через рибосомы.
3) Рибосомы - это долгоиграющие структуры. Их пул наращивается и работает постоянно на повышенный синтез белка. Но на такое наращивание пула рибосом требуется некий период времени постоянных запросов - то есть как минимум три недели систематического тренинга.
Сообщение изменено: Михалы4 (14 января 2022 - 02:56)